Table 4 Hazard ratios and 95% confidence intervals for mosaic loss of the Y chromosome and all-cause mortality using age as the underlying time metric and stratified by baseline characteristics.

From: Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

  mLOY (mLRR <−0.15) mLOY (mLRR <−0.40) mLRR d
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
Age a
<65 years 1.15 (0.97–1.37) 0.10 1.43 (0.96–2.12) 0.08 1.01 (0.99–1.04) 0.43
≥65 years 1.05 (0.91–1.22) 0.51 1.35 (1.02–1.79) 0.04 1.02 (1.00–1.05) 0.04
Smoking status b
Never smoker 0.90 (0.67–1.22) 0.50 1.10 (0.52–2.32) 0.80 1.00 (0.96–1.04) 0.91
Former smoker 1.20 (1.02–1.40) 0.03 1.43 (1.02–2.02) 0.04 1.03 (1.00–1.05) 0.03
Current smoker 1.19 (1.00–1.43) 0.06 1.51 (1.08–2.11) 0.02 1.03 (1.01–1.06) 0.02
Self-reported health c
Excellent/Good 1.08 (0.92–1.26) 0.35 1.34 (0.96–1.87) 0.09 1.01 (0.99–1.04) 0.35
Fair/Poor 1.06 (0.91–1.24) 0.47 1.36 (0.99–1.86) 0.06 1.02 (0.99–1.04) 0.17
  1. aMultivariable model is adjusted for age (as the underlying time metric), detailed smoking history (25-level variable incorporating current smoking status, smoking intensity (current and former smokers); time since quitting (former smokers), and cigar and pipe use (current and former smokers)); time to first cigarette among current smokers (<5 minutes, 5 to 15 minutes, 30 minutes to 1 hour, or >1 hour)); race/ethnicity (white, black, Asian, mixed, or other race); alcohol drinking (never drinker, former drinker, infrequent drinker (<1 drink/week), occasional drinker (>1 drink/week but <1 drink/day), moderate daily drinker (1 to 3 drinks/day), or heavy daily drinker (>3 drinks/day); general health status (excellent, good, fair, or poor); education level (college or university degree, A levels/AS levels or equivalent, O levels/GCSEs or equivalent, CSEs or equivalent, NVQ or HND or HNC equivalent, or other professional qualifications); body mass index (<18.5, 18.5 to <25, 25 to <30, 30 to <35, or ≥35 kg/m2); and physical activity (>10 minutes of moderate of vigorous activity 0, 1-2, 3-4, or ≥5 days/week).
  2. bSmoking stratified models were not adjusted for detailed smoking history.
  3. cSelf-reported health stratified models were not adjusted for self-reported health.
  4. dScaled by the - (standard deviation) of mLRR such that the HR corresponds to a one standard deviation decrease in mLRR. Abbreviations: CI, confidence interval; HR, hazard ratio; mLOY, mosaic loss of the Y chromosome; mLRR, median log2 intensity ratio of the Y chromosome.