Table 3 Hazard ratios and 95% confidence intervals for mosaic loss of the Y chromosome and cause-specific mortality using age as the underlying time metric (N = 223, 338).

From: Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

  mLOY (mLRR <−0.15) mLOY (mLRR <−0.40) mLRRb
HRa 95% CI P-value HRa 95% CI P-value HRa 95% CI P-value
Cancer mortality 1.04 (0.89-1.21) 0.62 1.48 (1.10-1.99) 0.01 1.02 (0.99-1.04) 0.19
No. deaths with mLOY/total deaths 174/4397    44/4397      
Respiratory system cancer mortality 1.03 (0.77-1.39) 0.87 1.65 (0.98-2.75) 0.06 1.05 (1.01-1.10) 0.01
No. deaths with mLOY/total deaths 48/840    15/840      
Digestive system cancer mortality 0.88 (0.65-1.19) 0.4 1.19 (0.64-2.23) 0.58 0.98 (0.94-1.02) 0.35
No. deaths with mLOY/total deaths 43/1464    10/1464      
Cardiovascular disease mortality 1.05 (0.83-1.32) 0.70 0.93 (0.52-1.64) 0.79 1.00 (0.97-1.04) 0.91
No. deaths with mLOY/total deaths 77/2069    12/2069      
Ischemic heart disease mortality 1.05 (0.78-1.40) 0.77 1.13 (0.59-2.19) 0.71 1.01 (0.97-1.06) 0.58
No. deaths with mLOY/total deaths 48/1322    9/1322      
Stroke mortality 1.56 (0.94-2.57) 0.08 0.96 (0.24-3.90) 0.96 1.02 (0.94-1.11) 0.67
No. deaths with mLOY/total deaths 17/293    2/293      
  1. aMultivariable model is adjusted for age (as the underlying time metric), detailed smoking history (25-level variable incorporating current smoking status, smoking intensity (current and former smokers); time since quitting (former smokers), and cigar and pipe use (current and former smokers)); time to first cigarette among current smokers (<5 minutes, 5 to 15 minutes, 30 minutes to 1 hour, or >1 hour)); race/ethnicity (white, black, Asian, mixed, or other race); alcohol drinking (never drinker, former drinker, infrequent drinker (<1 drink/week), occasional drinker (>1 drink/week but <1 drink/day), moderate daily drinker (1 to 3 drinks/day), or heavy daily drinker (>3 drinks/day); general health status (excellent, good, fair, or poor); education level (college or university degree, A levels/AS levels or equivalent, O levels/GCSEs or equivalent, CSEs or equivalent, NVQ or HND or HNC equivalent, or other professional qualifications); body mass index (<18.5, 18.5 to <25, 25 to <30, 30 to <35, or ≥35 kg/m2); and physical activity (>10 minutes of moderate of vigorous activity 0, 1-2, 3-4, or ≥5 days/week).
  2. bScaled by the - (standard deviation) of mLRR such that the HR corresponds to a one standard deviation decrease in mLRR. Abbreviations: CI, confidence interval; HR, hazard ratio; mLOY, mosaic loss of the Y chromosome; mLRR, median log2 intensity ratio of the Y chromosome.