Table 2 Hazard ratios and 95% confidence intervals for mosaic loss of the Y chromosome (mLOY) and all-cause mortality using age as the underlying time metric (N = 223, 338).

From: Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

  mLOY (mLRR <−0.15) mLOY (mLRR <−0.40) mLRRd
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
N (%) with mLOY 3,789 (1.70)    596 (0.27)      
No. deaths 8401    8401    8401   
No. deaths with mLOY 334    75      
Age-adjusteda 1.37 (1.23–1.53) 1.7 × 10−8 1.88 (1.50–2.36) 6.0 × 10−8 1.06 (1.04–1.08) 9.0 × 10−12
Age- & smoking-adjustedb 1.06 (0.95–1.18) 0.31 1.35 (1.08–1.70) 0.01 1.01 (0.99–1.03) 0.24
Multivariable-adjustedc 1.08 (0.97–1.21) 0.16 1.35 (1.08–1.70) 0.009 1.02 (1.00–1.03) 0.07
  1. aAdjusted for age using age as the underlying time metric in the Cox proportional hazards regression model.
  2. bAdditionally adjusted for detailed smoking history (25-level variable incorporating current smoking status, smoking intensity (current and former smokers); time since quitting (former smokers), and cigar and pipe use (current and former smokers).
  3. cAdditionally adjusted for race/ethnicity (white, black, Asian, mixed, or other race); alcohol drinking (never drinker, former drinker, infrequent drinker (<1 drink/week), occasional drinker (>1 drink/week but <1 drink/day), moderate daily drinker (1 to 3 drinks/day), or heavy daily drinker (>3 drinks/day)); general health status (excellent, good, fair, or poor); education level (college or university degree, A levels/AS levels or equivalent, O levels/GCSEs or equivalent, CSEs or equivalent, NVQ or HND or HNC equivalent, or other professional qualifications); body mass index (<18.5, 18.5 to <25, 25 to <30, 30 to <35, or ≥35 kg/m2); and physical activity (>10 minutes of moderate of vigorous activity 0, 1-2, 3-4, or ≥5 days/week).
  4. dScaled by the - (standard deviation) of mLRR such that the HR corresponds to a one standard deviation decrease in mLRR. Abbreviations: CI, confidence interval; HR, hazard ratio; mLOY, mosaic loss of the Y chromosome; mLRR, median log2 intensity ratio of the Y chromosome.