Table 1 Baseline characteristics and mosaic loss of the Y chromosome.

From: Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

  Entire Cohort mLOY (mLRR <−0.15) mLOY (mLRR <−0.40) mLRR
N (%) N (%) Adj. P-valuea N (%) Adj. P-valuea median ± SD Adj. P-valuea
Age
<65 years 187,711 (84.0) 1,901 (50.2) ref 260 (43.6) ref 0.007 ± 0.052 ref
≥65 years 35,627 (16.0) 1,888 (49.8) <4.9 × 10−324 336 (56.4) 4.6 × 10−99 −0.008 ± 0.085 <4.9 × 10−324
Smoking status
Never smoker 108,859 (49.0) 1,012 (26.9) ref 126 (21.2) ref 0.007 ± 0.051 ref
Former smoker 85,537 (38.5) 1,808 (48.0) 2.8 × 10−24 282 (47.5) 2.8 × 10−8 0.003 ± 0.063 1.2 × 10−18
Current smoker 27,748 (12.5) 946 (25.1) 7.8 × 10−184 186 (31.3) 7.9 × 10−50 0.001 ± 0.076 1.0 × 10−281
Race/Ethnicity
White 210,179 (94.6) 3,679 (97.7) ref 586 (98.5) ref 0.004 ± 0.060 ref
Mixed Race 1,070 (0.5) 5 (0.1) 0.06 1 (0.2) 0.51 0.009 ± 0.051 0.36
Asian 5,671 (2.6) 49 (1.3) 0.13 6 (1) 0.26 0.010 ± 0.050 0.001
Black 3,285 (1.5) 12 (0.3) 0.003 0 (0) 0.96 0.017 ± 0.044 1.6 × 10−16
Other 1,882 (0.8) 19 (0.5) 0.77 2 (0.3) 0.62 0.012 ± 0.048 0.01
Self-reported health status
Excellent 34,777 (15.7) 480 (12.8) ref 68 (11.5) ref 0.005 ± 0.055 ref
Good 124,573 (56.1) 2,074 (55.1) 0.30 316 (53.3) 0.49 0.005 ± 0.058 0.58
Fair 51,063 (23) 971 (25.8) 0.03 166 (28) 0.08 0.005 ± 0.062 0.91
Poor 11,527 (5.2) 239 (6.4) 0.009 43 (7.3) 0.06 0.004 ± 0.069 0.07
Body mass index
Underweight (<18.5 kg/m2) 483 (0.2) 7 (0.2) 0.25 1 (0.2) 0.46 0.005 ± 0.055 0.38
Normal (18.5 to <25 kg/m2) 53,505 (24.4) 914 (24.7) ref 151 (25.9) ref 0.004 ± 0.060 ref
Overweight (25 to <30 kg/m2) 108,768 (49.7) 1,942 (52.5) 0.50 310 (53.1) 0.57 0.004 ± 0.060 0.003
Obese I (30 to <35 kg/m2) 43,676 (19.9) 675 (18.3) 0.0001 98 (16.8) 0.01 0.005 ± 0.058 2.7 × 10−12
Obese II/III (≥35 kg/m2) 12,609 (5.8) 159 (4.3) 0.0006 24 (4.1) 0.07 0.008 ± 0.057 6.7 × 10−17
Physical activity (>10 minutes of moderate or vigorous activity)
0 days/week 23,637 (11.4) 430 (12.7) 0.21 79 (15.0) 0.08 0.004 ± 0.061 0.14
1 or 2 days/week 28,237 (13.6) 413 (12.2) 0.75 57 (10.8) 0.46 0.005 ± 0.056 0.16
2 or 3 days/week 35,005 (16.8) 569 (16.8) 0.91 86 (16.3) 0.91 0.005 ± 0.058 0.35
≥5 days/week 121,165 (58.2) 2,002 (59.1) ref 304 (57.8) ref 0.005 ± 0.059 ref
Alcohol drinking status
Never drinker 6,243 (2.8) 78 (2.1) 0.40 11 (1.8) 0.69 0.008 ± 0.055 0.14
Former drinker 7,883 (3.5) 144 (3.8) 0.56 23 (3.9) 0.70 0.003 ± 0.062 0.50
Current drinker (<1 drink/week) 36,187 (16.2) 553 (14.6) 0.37 88 (14.8) 0.82 0.006 ± 0.059 0.51
Current drinker (≥1 drink/week >7) 44,922 (20.2) 686 (18.2) 0.38 111 (18.6) 0.74 0.005 ± 0.058 0.66
Current drinker (1 to 3 drinks/day) 95,935 (43.1) 1,621 (42.9) ref 249 (41.8) ref 0.004 ± 0.059 ref
Current drinker (>3 drinks/day) 31,550 (14.2) 698 (18.5) 0.0005 114 (19.1) 0.13 0.004 ± 0.065 0.27
College or university degree 75,324 (41.4) 953 (36.3) ref 133 (32.8) ref 0.006 ± 0.054 ref
Education level
A levels/AS levels or equivalent 22,915 (12.6) 322 (12.3) 0.28 60 (14.8) 0.04 0.006 ± 0.058 0.22
O levels/GCSEs or equivalent 41,341 (22.7) 677 (25.8) 0.25 100 (24.7) 0.78 0.005 ± 0.057 0.53
CSEs or equivalent 12,048 (6.6) 79 (3.0) 0.91 14 (3.5) 0.46 0.009 ± 0.050 0.68
NVQ or HND or HNC or equivalent 20,204 (11.1) 384 (14.6) 0.55 64 (15.8) 0.34 0.004 ± 0.061 0.2
Other qualifications 9,992 (5.5) 213 (8.1) 0.73 34 (8.4) 0.87 0.002 ± 0.064 0.58
Diabetes diagnosis
No 206,681 (93.0) 3,451 (91.5) ref 545 (91.6) ref 0.005 ± 0.059 ref
Yes 15,507 (7.0) 319 (8.5) 0.003 50 (8.4) 0.14 0.004 ± 0.065 5.6 × 10−13
Cancer (other than non-melanoma skin cancer) diagnosis
No 211,208 (94.6) 3,463 (91.4) ref 541 (90.8) ref 0.005 ± 0.059 ref
Yes 12,130 (5.4) 326 (8.6) 0.61 55 (9.2) 0.94 0.001 ± 0.069 0.14
Heart attack or stroke diagnosis
No 211,710 (94.8) 3,399 (89.7) ref 530 (88.9) ref 0.005 ± 0.058 ref
Yes 11,628 (5.2) 390 (10.3) 0.01 66 (11.1) 0.32 −0.002 ± 0.075 1.4 × 10−10
  1. aAdjusted P-values (Adj. P-value) from multivariable logistic regression models are adjusted for all other covariates in Table 1. In this multivariable adjusted model, we fit parameters for continuous age and age-squared. Abbreviations: mLOY, mosaic loss of the Y chromosome; mLRR, median log2 intensity ratio of the Y chromosome.