Flt3 ligand pretreatment reduces the morbidity, mortality, and tissue viral loads of EV-A71-infected mice. The disease scores (A) and survival rates (B) of infected mice, which were pretreated with saline (n = 14) or Flt3 ligand (n = 10), are shown. (C) The indicated tissues and organs of mice pretreated with saline (n = 6) or Flt3 ligand (n = 7) were harvested on day 7 post-infection to determine viral titers. In panels A and C, data represent means ± or + SEs. *P < 0.05; **P < 0.01; and ***P < 0.001.