Table 4 Multivariate analysis for evaluating the risk of sepsis in the validation cohort based on the PCT/HLA-DRA ratio or Procalcitonin levels.

From: Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients

  Multivariate analysis for PCT/HLA-DRA ratio Multivariate analysis for PCT
OR [CI 95%] p OR [CI 95%] p
SOFA score 0.94 0.71 1.25 0.690 1.00 0.77 1.30 0.992
Cancer 0.17 0.02 1.34 0.092 0.20 0.03 1.34 0.097
Urgent Surgery 45.68 2.80 744.81 0.007 31.87 2.95 344.67 0.004
Neutrophil concentration in blood (cells/mm3) 1.00 1.00 1.00 0.471 1.00 1.00 1.00 0.754
C Reactive Protein 1.00 0.98 1.02 0.941 1.01 0.99 1.02 0.503
PCT/HLA-DRA > OOP (0.0003) 34.86 1.22 995.08 0.038
PCT > OOP (1.115 ng/mL) 5.52 0.40 75.78 0.201
  1. Optimal operating points (OOP) obtained in the derivation cohort were tested in the validation cohort.