Table 3 Multivariate analysis for evaluating the risk of sepsis in the derivation cohort based on the PCT/HLA-DRA ratio or Procalcitonin levels.

From: Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients

  Multivariate analysis for PCT/HLA-DRA ratio Multivariate analysis for PCT
OR [CI 95%] p OR [CI 95%] p
SOFA Score 1.47 1.16 1.87 0.002 1.49 1.17 1.90 0.001
Age 1.00 0.94 1.06 0.873 1.01 0.96 1.07 0.714
Urgent Surgery 45.70 7.02 297.33 <0.001 41.57 6.77 255.39 <0.001
Chronic Renal Failure 8.09 0.40 165.00 0.174 4.74 0.26 86.12 0.293
Cancer 1.08 0.29 4.00 0.908 1.24 0.33 4.60 0.748
Diabetes Mellitus 2.89 0.69 12.22 0.149 2.41 0.61 9.57 0.210
Neutrophil concentration in blood (cells/mm3) 1.00 1.00 1.00 0.467 1.00 1.00 1.00 0.436
C-Reactive Protein 1.00 1.00 1.01 0.026 1.00 1.00 1.01 0.021
PCT/HLA-DRA > OOP (0.0003) 7.66 1.82 32.29 0.006
PCT > OOP (1.115 ng/mL) 4.21 1.15 15.43 0.030
  1. OOP: Optimal operating point.