Table 3 In vitro release kinetic values of GnRH [6-D-Phe] from selected Zn2+: GnRH [6-D-Phe] oil depot formulations.

From: Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils

Formulation First-ordera R2 Higuchib R2 Zero-orderc R2 Korsmeyer-Peppasd R2 n
10:1_complex_OV1 0.8574 0.9416 0.7589 0.9784 24.342
10:1_complex_OV2 0.8214 0.8848 0.7087 0.9296 18.314
10:1_in situ complex_OV1 0.5505 0.7552 0.5092 0.9533 16.491
10:1_in situ complex_OV2 0.6654 0.7891 0.5836 0.8960 13.566
GnRH [6-D-Phe]_OV1 0.5405 0.7460 0.4949 0.9471 27.433
GnRH [6-D-Phe]_OV2 0.0721 0.2894 0.1229 0.5010 19.913
  1. aFirst-order equation, log Q = Log Q0 − kt/2.303; bHiguchi equation, Q = kt½; cZero-order equation, Q = Q + kt; dKorsmeyer-Peppas equation, Qt/Qµ = ktn.