Table 1 Clinicopathologic characteristics and frequency of circulating wt p53-specific tet264–272+ CD8+ T cells in 33 patients with HNSCC who donated PBMC for this study.

From: Phenotype of p53 wild-type epitope-specific T cells in the circulation of patients with head and neck cancer

Characteristics Patients n (%) High frequency n (%) Medium frequency n (%) Low frequency n (%) Negative n (%)
Age (years)
  Mean range 42–82     
  <60 16 (48) 2 (29) 5 (63) 6 (50) 3 (50)
  ≥60 17 (52) 5 (71) 3 (37) 6 (50) 3 (50)
Gender
  Male 26 (79) 6 (86) 6 (75) 8 (67) 6 (100)
  Female 7 (21) 1 (14) 2 (25) 4 (33) 0 (0)
Primary tumor cite
  Oral cavity 7 (21) 1 (14) 1 (13) 4 (33) 1 (17)
  Oropharynx 16 (48) 4 (57) 5 (61) 4 (33) 3 (50)
  Larynx 6 (18) 2 (29) 1 (13) 1 (8) 2 (33)
  Others 4 (12) 0 (0) 1 (13) 3 (26) 0 (0)
Primary tumor stage*
  T1 15 (45) 5 (72) 4 (50) 2 (9) 4 (67)
  T2 7 (21) 1 (14) 2 (24) 2 (9) 2 (33)
  T3 8 (24) 1 (14) 1 (13) 6 (73) 0 (0)
  T4 3 (10) 0 (0) 1 (13) 2 (9) 0 (0)
Nodal status*
  N0 16 (48) 6 (86) 5 (63) 3 (26) 2 (33)
  N1 7 (21) 0 (0) 2 (25) 2 (9) 3 (50)
  N2 10 (30) 1 (14) 1 (12) 7 (65) 1 (17)
Tumor differentiation
  Well 5 (15) 1 (14) 2 (25) 1 (8) 1 (17)
  Moderate 24 (73) 6 (86) 6 (75) 9 (74) 3 (49)
  Poor 2 (6) 0 (0) 0 (0) 1 (8) 1 (17)
  Undifferentiated 2 (6) 0 (0) 0 (0) 1 (8) 1 (17)
Tumor p53 protein accumulation
  Positive 18 (55) 0 (0) 3 (37) 10 (83) 5 (83)
  Negative 15 (45) 7 (100) 5 (63) 2 (17) 1 (17)
p16 expression
  Positive 9 (27) 2 (29) 5 (63) 1 (8) 1 (17)
  Negative 24 (73) 5 (71) 3 (37) 11 (91) 5 (83)
Therapy
  Surgery only 18 (55) 6 (86) 4 (50) 4 (33) 4 (67)
  Surgery + radiation therapy 10 (30) 1 (14) 2 (25) 5 (42) 2 (33)
  Surgery + chemoradiotherapy 2 (15) 0 (0) 2 (25) 3 (25) 0 (0)
  1. *TNM classification of malignant tumors according UICC 7th ed.