Figure 1 | Scientific Reports

Figure 1

From: TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain

Figure 1

TMUB1 expression. (A) Western blot analysis of TMUB1 in the sham-operated (SPH) group and partial hepatectomy (PH) groupat 0, 12, 24, 48, and 72 hours. TMUB1 expression significantly increased after PH until 48 hours, and then the expression decreased gradually (n = 3, *P < 0.05, **P < 0.01, t-test) (B) mRNA expression of Tmub1 between the SPH and PH groups were in agreement with the protein changes in proliferative cells. (n = 3, *P < 0.05, **P < 0.01, t-test). (C) Western blot analysis of TMUB1 in the M phase and G1/S phase. The expression of TMUB1 significantly decreased in the M phase and increased in the G1/S phase (n = 3, *P < 0.05, **P < 0.01, ANOVA); (D) Western blot analysis of TMUB1 in the G0/G1 phase. The expression of TMUB1 did not change in the beginning of the G0/G1 phase (0–8 hours) but significantly decreased at the end of this phase (10 and 12 hours) (n = 3, *P < 0.05, **P < 0.01, ANOVA).

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