Figure 5 | Scientific Reports

Figure 5

From: Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome

Figure 5

Langerhans islet gene expression analyses after 19 weeks of liraglutide treatment compared to WT saline group. Gene expression of (a) Wolframin1; (b) GLP-1 receptor; ER stress markers (c) Grp78 and (d) Xbp1 splicing; inflammation marker (e) IP10; proliferation marker (f) Ki67. The data were compared using factorial ANOVA followed by Tukey’s HSD tests; *p < 0.05, **p < 0.01, ***p < 0.001 compared to WT animals of the same treatment; #p < 0.05, ##p < 0.01 compared to saline animals of the same GT. The data are presented as the mean ± SEM, n = 4–8.

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