Table 4 Investigation of ring B.

From: Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

  Ring B hSUCNR1 mSUCNR1 ClogPb
pEC50 (efficacy, %)a
3c 5.75 ± 0.08 (72.8 ± 2.6) 6.46 ± 0.06 (79.3 ± 1.6) 1.66
25 5.91 ± 0.11 (49.7 ± 3.9) 5.40 ± 0.13 (58.0 ± 4.5) 2.27
26 4% @10−4M 7% @10−4M 2.27
27 6.03 ± 0.25 (78.2 ± 8.0) 6.10 ± 0.17 (89.3 ± 6.1) 2.05