Figure 1 | Scientific Reports

Figure 1

From: Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior

Figure 1

Theta-burst stimulation protocol. (a) Using an individual anatomical MRI image and a stereotaxic frameless Brainsight neuronavigation system, theta burst stimulation (TBS) was applied over the right inferior lateral prefrontal cortex (MNI: x = 48, y = 35, z = −2). Coordinates were chosen based on former neuroimaging findings, suggesting that the ilPFC is involved in the interplay of habitual and goal-directed behavior13. (b) TBS pulses were delivered in triple bursts, consisting of three magnetic pulses at an interval of 50 Hz. Bursts were delivered at an interval of 5 Hz. Participants received in total 600 pulses, in one of three TBS protocols that served as either inhibitory (cTBS), excitatory (iTBS) or sham stimulation (imTBS)18. Continuous (c) TBS consisted of 40 seconds continuous stimulation. Intermediate (im)TBS consisted of 5 second trains of active stimulation followed by a 10 second pause, lasting for a total of 110 seconds. Intermittent (i)TBS consisted of 2 second trains of active stimulation followed by an 8 second pause, lasting for a total of 190 seconds. In the no-stimulation control condition, participants did not receive any stimulation.