Parafoveal and perifoveal axial vascular density profiles (vascular density vs. scaled relative axial depth) obtained with optical coherence tomography angiography. An en face image is also shown for reference (A,F). Profiles in parafoveal region (2.5°–3.75° radial distance to the foveal center) were obtained from the superior (B), nasal (C), temporal (D), and inferior (E) quadrants (red shaded regions in A). Profiles in the perifoveal region (6.25°–7.5° radial distance to the foveal center) were obtained from the superior (G), nasal (H), temporal (I), and inferior (J) quadrants (red shaded regions in F). Individual patient profiles are shown as grey solid lines and mean density is shown as a green solid line. The green dotted lines represent one standard deviation above and below the mean. Sharp peaks, corresponding to the intermediate and deep capillary plexuses, are apparent near the inner and outer INL borders in all examined parafoveal regions. The superficial vascular plexus contained both a small peak at the NFL-GCL junction and a larger, broader peak within the GCL. In all four perifoveal regions, sharp peaks corresponding to the intermediate and deep capillary plexuses are apparent near the inner and outer INL borders in all examined regions. Unlike in the parafoveal region, the SVP was not comprised of two distinct peaks. The tall SVP peak was shifted towards the ILM in the nasal, superior, and inferior quadrants. NFL: nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer.