Table 2 Distribution of small intestinal mast cells.

From: Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse

  Mast cells/field (All fields) Mast cells/field (GALT fields) Mast cells/field (Other fields) Mast cells/field (Skin)
Wild type 0.07 ± 0.03 0.35 ± 0.28 0.04 ± 0.02 11.5 ± 0.8
Kcnn4 −/− 0.10 ± 0.04 0.16 ± 0.12 0.10 ± 0.05 12.3 ± 2.0
Cftr ΔF508/ΔF508 0.41 ± 0.18a 1.46 ± 0.04b,c 0.14 ± 0.05 12.2 ± 1.2
CftrΔF508/ΔF508/Kcnn4−/− 0.18 ± 0.03 0.40 ± 0.19 0.15 ± 0.05 12.1 ± 0.4
Cftrfl/fl/VillinCre/− 0.06 ± 0.02 0.20 ± 0.05 0.04 ± 0.02  ± 0.5
Wild type 0.08 ± 0.04 0.40 ± 0.30 0.03 ± 0.02 13.2 ± 3.0
Stat6 −/− 0.08 ± 0.03 0.18 ± 0.09 0.04 ± 0.01 12.0 ± 2.0
Cftr ΔF508/ΔF508 0.26 ± 0.07d 1.20 ± 0.32e 0.10 ± 0.06 13.8 ± 0.8
CftrΔF508/ΔF508/Stat6−/− 0.19 ± 0.08 0.69 ± 0.29 0.06 ± 0.02 13.6 ± 1.8
  1. GALT: Gut associated lymphoid tissue.
  2. Values are given as mean ± S.E.M. Unpaired Student’s test.
  3. aIndicates p = 0.008,
  4. bp = 0.032,
  5. dp = 0.032 and
  6. ep = 0.032 vs corresponding wild type group.
  7. cIndicates p = 0.032 vs CftrΔF508/ΔF508/Kcnn4−/−; 80 to 120 400x optical fields per animal were analysed and n = 4–5 animals per group were used.