Figure 5 | Scientific Reports

Figure 5

From: Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse

Figure 5

Effect of mast cell ablation or Stat6 silencing on the survival of CF mice. (A) Circulating IgE levels were determined in the double and single mutant animals. Figures represent individual animals and red lines means ± S.E.M. Mann-Whitney test: *indicates p < 0.05 and n.s. (non-statistical difference) compared to the corresponding control. (B) Mast cell ablation in double mutant C-kitW-sh/W-sh/CftrΔF508/ΔF508 mice did not change the survival of these CF mice. Log-Rank test: *indicates p = 0.001 and #p = 0.002. (C) Silencing of Stat6 significantly reduced lethality of the CF animals. Log-Rank test: *indicates p = 0.0002 and #p = 0.04.

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