Figure 1 | Scientific Reports

Figure 1

From: Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse

Figure 1

Increased survival of CftrΔF508/ΔF508 mice by additional Kcnn4 inactivation. (A) Kaplan-Meier curves showing increased survival for the double mutant CftrΔF508/ΔF508/Kcnn4−/− mouse compared to CftrΔF508/ΔF508. Log-Rank test, *indicates p = 0.001, n = 30 per group. (B) Photographs of animals of the four genotypes at 60 days old. Notice that the double mutant showed similar size to the CF mouse. Bar = 1 cm. (C) Time course for weight gain of animals of different genotypes. Break of the curves at day 21 corresponds to weaning. Values are given as mean ± S.E.M. with n = 8–9 per group. Calculated weight rates after and before weaning are summarized in Table 1.

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