Clinical improvement of psoriasis of an 8-week course of hydrogen-water bathing therapy. Case 1: A 64-year-old psoriasis patient at baseline (PASI 16.4, a,b) and after the bathing therapy (PASI 1.8, c,d). Although he had been treated with acitretin capsules 30 mg daily for more than 4 months, the psoriatic lesions had not improved except for the partially reduced scale on the plaque. He refused to increase the drug dose due to intolerable dryness and chapping of the mucous membranes. Case 2: A 40-year-old psoriasis patient at baseline (PASI 21.1, a,b) and after the last bathing therapy (PASI 4.1, c,d). He complained of severely itching and treatment-resistant lesions (acitretin capsules 40 mg daily for more than 6 months), and after bathing therapy he was able to reduce the dose. Case 3: A 43-year-old psoriasis patient at baseline (PASI 20.2, a,b) and after the last bathing therapy (PASI 4.8, c,d). This man had been continuously treated with methotrexate 5 mg weekly for more than 10 months and was able to reduce the dose successfully after bathing therapy. Note that patients experienced similar responses in the areas not shown.