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Figure 1

From: A direct tissue-grafting approach to increasing endogenous brown fat

Figure 1

Concept of tissue-engineering therapeutic approach to increase endogeneous brown fat via a single-step ex vivo browning method. Illustration of 3-step process for increasing brown adipose tissue (BAT) in humans through ex vivo browning: (1) subcutaneous white adipose tissue (WAT) is harvested by liposuction or excision and cultured as tissue fragments; (2) WAT fragments are exposed to chronic browning stimuli (i.e. browning factors in the media) to convert the WAT to BAT, in a process that takes approximately 1 to 3 weeks; (3) the converted BAT fragments are autologously reimplanted within WAT.

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