Figure 8 | Scientific Reports

Figure 8

From: Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression

Figure 8

Propranolol and 2DG together inhibit tumor growth in vivo. 2 × 106 PC3 cells were injected subcutaneously in each flank of nude mice (n = 20 mice). The tumors were allowed to grow for 11 days and then the animals were separated in four groups (n = 10 tumors in each condition). Each group received a specific treatment: Control (PBS), propranolol (P), 2DG (2DG) and 2DG+P (2DG+P) as described in the “Materials and Methods”. After 16 days, mice were sacrificed. The tumors were macroscopically observed (a), measured (b) and weighed (c). The double treatment induced a significant reduction of tumor size and weight. Bar = 5 mm.