Figure 9 | Scientific Reports

Figure 9

From: Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon

Figure 9

Sensitivity of additional NAD(P)H fluorescence lifetime components to FX11 and DCA treatment in cells. (a) Mean and standard deviations of NAD(P)H \({\alpha }_{1}\), \({\tau }_{1}\), and \({\tau }_{m}\) in MCF10A cells after 48 hours of 10 μM FX11 treatment vs. vehicle. (b) Mean and standard deviations of NAD(P)H \({\alpha }_{1}\), \({\tau }_{1}\), and \({\tau }_{m}\) in MCF10A cells after 48 hours of 50 mM DCA treatment vs. vehicle. (c) Mean and standard deviations of NAD(P)H \({\alpha }_{1}\), \({\tau }_{1}\), and \({\tau }_{m}\) in HPDE6 cells after 48 hours of 10 μM FX11 treatment vs. vehicle. (d) Mean and standard deviations of NAD(P)H \({\alpha }_{1}\), \({\tau }_{1}\), and \({\tau }_{m}\) in HPDE6 cells after 48 hours of 50 mM DCA treatment vs. vehicle. n = 3–4 experiments each.

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