Table 1 Dose response data of modulators. Data are presented as mean ± SD, (n = 3).

From: Natural polyphenols as sirtuin 6 modulators

  Compound IC50 value (µM)
4 (−)-Catechin gallate 2.5 ± 0.03
5 (−)-Gallocatechin gallate 5.4 ± 0.04
  Compound EC 50 value ( µ M) Maximal activation (fold)
13 Luteolin14 270 ± 25 6.1
14 Kaempferol n.d 3.0
15 Quercetin14 990 ± 250 10
16 Myricetin 404 ± 20 7.7
17 Cyanidin 460 ± 20 55
18 Delphinidin 760 ± 200 6.3