Table 3 The stromal inflammation (SI) score is significantly associated with overall survival in multivariate Cox proportional hazard (CPH) analyses for the full TMA dataset (n = 423 complete cases). The variables in the table are ordered by p-values (most significant listed first). Only the variables listed are part of the CPH analyses. The SI score is highlighted. The results for observers 1 (this table) and 2 (see Supplementary Table 3) were similar.

From: Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma

Variable Hazard ratio (95% CI) P-value
Overall stage 1.59 (1.36–1.85) 2.7 × 10−9
Age (years) 1.04 (1.02–1.05) 6.3 × 10−8
Vascular invasion 1.84 (1.44–2.37) 1.3 × 10−6
SI score 0.32 (0.19–0.54) 2.5 × 10 −5
Pleural invasion 1.16 (0.90–1.50) 0.26
Tumor grade 1.11 (0.88–1.39) 0.39