Table 2 The stromal inflammation (SI) score is significantly associated with overall survival in the univariate Cox proportional hazards model for the full TMA dataset (n = 437). This list of variables is ordered by p-values (most significant listed first). The SI score is highlighted. The values for observers 1 and 2 are separated by “/.”

From: Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma

Variable Type of variable Hazard ratio (95% CI) P-value
Overall stage Clinical 1.64 (1.42–1.90) 1.5 × 10−11
Vascular invasion Histologic 2.27 (1.79–2.89) 1.7 × 10−11
T Clinical 1.53 (1.33–1.77) 3.2 × 10−9
Age (years) Clinical 1.03 (1.02–1.05) 5.5 × 10−7
M Clinical 3.46 (2.10–5.71) 1.1 × 10−6
N Clinical 1.40 (1.21–1.63) 7.5 × 10−6
SI score (observers 1/2) Histologic (this study) 0.30 (0.18–0.51)/0.31 (0.18–0.55) 7.4 × 10−6/5.7 × 10−5
Tumor size (cm) Clinical 1.10 (1.05–1.16) 1.1 × 10−4
Pleural invasion Histologic 1.48 (1.17–1.90) 0.0013
Tumor grade Histologic 1.14 (0.91–1.42) 0.23
Gender (M/F) Clinical 0.84 (0.64–1.12) 0.25
Pack years Clinical 1.00 (0.99–1.00) 0.71