Figure 4 | Scientific Reports

Figure 4

From: Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma

Figure 4

The relationship between SI, PD-L1 expression, and overall survival. (A and B) PD-L1 expression was not strongly associated with inflammation. (A) By gene expression profiling, CD274 (PD-L1) RNA levels did not correlate strongly with RNA levels of genes expressed by immune cells in lung SCC TCGA cases. The numbers in each box are the Spearman rho values for the expression levels of the gene-pair combinations (red = high correlation; white = low correlation). (B) PD-L1 protein expression by immunohistochemistry did not correlate strongly with histologic SI scores in lung SCC TMA cases (Spearman rho = 0.20). (C and D) The prognostic value of the SI score is modified by epithelial PD-L1 expression. Cases from the TMA cohorts were separated by PD-L1 expression (high versus low). (C) SI and survival when PD-L1 expression was low. (D) SI and survival when PD-L1 expression was high. The interaction term for this Cox proportional hazards model was trending towards significance (interaction p-values = 0.056). The results from observer 1 (this Figure) and observer 2 (Supplementary Figure 4) were similar.

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