Map of the phosphoinositide pathway. Red arrows represent fluxes of phosphorylation and blue arrows fluxes of hydrolysis. For each flux, the name (vi→j) and the group of enzymes that catalysed the reaction are shown. Black arrows represent influxes and effluxes of material entering and leaving the system. SIOSS is a group of phosphatases, consisting of SYNJ 1/2, INPP5 B/J/E, OCRL1, SAC2 and SKIP. PI4K + PIP5KI + DVL denotes a complex formed by the three proteins. Proteins separated by commas catalyzed the same reaction. SYNJ: Synaptojanins; INPP5: Inositol polyphosphate 5-phosphatases; OCRL1: Lowe Oculocerebrorenal Syndrome Protein; SAC2: Suppressor of actin ;SKIP: Skeletal muscle and kidney enriched inositol polyphosphate phosphatase.