Figure 2 | Scientific Reports

Figure 2

From: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations

Figure 2

Gene expression determined by RNA-seq distinguishes CAP from CFP tissues. (A) Dendrogram based on average distance of the whole transcriptome between the CAP tissues (red) and CFP tissues (blue). Each patient ID beginning with the letter A is shown. (B) A volcano plot showing all differentially expressed genes between the CAP and CFP tissues. The x-axis is the log of the fold change in expression, and the y-axis is the log of the FDR between CAP and CFP tissues. Green dots are genes that have a fold change > 2, and FDR > 0.1. For a list of genes that are above these thresholds and colored green see Supplementary Table S6 (C) Boxplot of CXCL5 gene expression for CAPs (peach) and CFPs (teal) polyp tissues. Y-axis is the log2 of the gene counts. The inset shows the boxplots for the normal and polyp tissues from CAP patients (left) and CFP patients (right) for CXCL5, showing the relative change between normal and polyp. Similar boxplots are also shown for (D) GREM1, (E) IGF2, (F) CTGF, and (G) PLAU.

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