Table 1 Study of the reversibility by dialysis of the effects of SSR411298 and PMSF on mouse brain FAAH activity.

From: The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents

Treatment Concentration [3H]ethanolamine production (% control)
T = 0 T = 16 to 18 hours
Non dialyzed Dialyzed
Control   100 ± 2 100 ± 2 100 ± 3
SSR411298 50 nM 29 ± 4 41 ± 3 73 ± 4*
100 nM 22 ± 3 38 ± 5 68 ± 8*
200 nM 16 ± 3 30 ± 4 74 ± 5*
PMSF 10 µM 28 ± 7 37 ± 4 34 ± 7
25 µM 19 ± 4 26 ± 3 27 ± 8