Effect of SSR411298 and fluoxetine in two models of depression: (A) the chronic mild stress procedure in mice. Data are expressed as mean physical state score ± SEM. #P < 0.01 (Wilcoxon test versus non stressed control group), *P < 0.05, **P < 0.001 (Kruskal Wallis one sided upper multiple comparison tests with Bonferroni-Holm correction versus stressed control group). N = 14 to 20 mice per group; (B) the forced-swimming test in rats. SSR411298 was administered p.o. twice a day during 2 days, 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing. Fluoxetine was administered p.o. twice (immediately after the first session, and 60 minutes before session 2). Data represent mean+SEM. *P < 0.05, **P < 0.01 and ***P < 0.001. N = 6–7 rats per group.