Table 1 Summary of epidemiological and clinical characteristics of septic shock patients who underwent major surgery according to CD14 polymorphism.

From: Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

Characteristics All Patients CD14 rs2569190 polymorphism
AA/AG GG p-value(*)
No. patients 205 152 53
Gender (male) 131 (63.9%) 100 (65.8%) 31 (58.5%) 0.341
Age (years) 73. (63; 79.5) 72 (63; 79.7) 77 (67.5; 79.5) 0.137
Prior or pre-existing conditions
 Smoker 36 (17.6%) 27 (17.8%) 9 (17.0%) 0.897
 Alcoholism 15 (7.3%) 9 (5.9%) 6 (11.3%) 0.194
 Obesity 30 (14.6%) 18 (11.8%) 12 (22.6%) 0.055
 Diabetes 26 (12.7%) 17 (11.2%) 9 (17.0%) 0.275
 Heart disease 92 (44.9%) 71 (46.7%) 21 (39.6%) 0.372
 Chronic obstructive pulmonary disease 36 (17.6%) 24 (15.8%) 12 (22.6%) 0.259
 Hypertension 112 (54.6%) 81 (53.3%) 31 (58.5%) 0.513
 Chronic kidney disease 30 (14.6%) 23 (15.1%) 7 (13.2%) 0.733
 Cancer 48 (23.4%) 31 (20.4%) 17 (32.1%) 0.084
 Liver disease 9 (4.4%) 6 (3.9%) 3 (5.7%) 0.600
Surgery
 Cardiac (versus abdominal) 82 (40.0%) 62 (40.8%) 20 (37.7%) 0.696
 Emergency (versus scheduled) 130 (63.4%) 97 (63.8%) 33 (62.3%) 0.840
Severity indexes
 SOFA score 9 (7; 10.5) 9 (7; 10) 9 (7; 11) 0.510
 APACHE II score 16 (14; 19) 16 (13; 19) 17 (14; 21.5) 0.060
Infection
 Gram-positive 102 (49.8%) 81 (53.3%) 21 (39.6%) 0.087
 Gram-negative 108 (52.7%) 78 (51.3%) 30 (56.6%) 0.507
 Fungus 41 (20.0%) 34 (22.4%) 7 (13.2%) 0.151
 Catheter bacteraemia 70 (34.1%) 55 (36.2%) 15 (28.3%) 0.297
 Surgical site infection 49 (23.9%) 35 (23.0%) 14 (26.4%) 0.618
 Urinary tract infection 24 (11.7%) 15 (9.9%) 9 (17.0%) 0.165
 Endocarditis 10 (4.9%) 8 (5.3%) 2 (3.8%) 0.665
 Peritonitis 96 (46.8%) 72 (47.4%) 24 (45.3%) 0.793
 Pneumonia 97 (47.3%) 69 (45.4%) 28 (52.8%) 0.351
  1. Values are expressed as absolute count (percentage) and median (percentile 25; percentile 75).
  2. (*)P-values were calculated by Chi-square test or Fisher’s exact test for categorical variables and Mann-Whitney test for continuous variables. Statistically significant differences are shown in bold.
  3. Note that patients may have had more than one organism cultured.
  4. Abbreviations: SOFA, sequential organ failure assessment; APACHE, acute physiology and chronic health evaluation; CD14, cluster of differentiation 14.