Figure 1 | Scientific Reports

Figure 1

From: A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

Figure 1

Domain architecture and NMR spectra of Rad50. (a) Cartoon representation of full length Rad50 (top) and Rad50NBD (bottom). (b) Crystal structure of P. furiosus Mre11HLH-Rad50NBD (3QKS)18. Colors in (a) and (b) illustrate conserved domains important for Rad50 function. (c) 2D 13C,1H methyl-TROSY HMQC25 spectrum of Mre11HLH-Rad50NBD collected at 14.1 T and 50 °C. The side chain methyl group assignments are given.

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