Table 1 Experimental groups and treatments.

From: Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis

Group (n) Treatments Dose (mg/kg) Schedule Duration
1 (10) Vehicle PBS 3 X /week; ip 12 weeks
2 (9) Cromolyn (low-dose) 1 3 X /week; ip 12 weeks
3 (8) Cromolyn (high-dose) 3.15 3 X /week; ip 12 weeks
4 (10) Ibuprofen (low-dose) 0.5 3 X /week; ip 12 weeks
5 (10) Ibuprofen (high-dose) 2 3 X /week; ip 12 weeks
6 (10) Combined low-dose (Cromolyn + Ibuprofen) 1 + 0.5 (respectively) 3 X /week; ip 12 weeks
7 (9) Combined high-dose (Cromolyn + Ibuprofen) 3.15 + 2 (respectively) 3 X /week; ip 12 weeks
  1. Three-month old Tg2576 mice were randomly assigned to 7 treatment groups and then acclimatized for 2 months at the study facility, followed by vehicle or drug treatment. The first was control group receiving vehicle (PBS) treatment (n = 10). The drug-treatment groups were divided to low and high-dose groups, receiving either ibuprofen, cromolyn or their combination (n = 8–10). All 7-group mice were IP injected based on 0.1 mL/30 g body weight for 3 times per week for 12 weeks and were sacrificed at 8-month old. Tissues were harvested and processed for post-mortem analysis.