Figure 3 | Scientific Reports

Figure 3

From: MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease

Figure 3

Prediction of target molecules of the selected miRs by in silico analysis. The target molecules of selected miRs are predicted using IPA tools. Hsa-miR-320a can interact with BMPR1A, and intracellular signaling via BMPR1A may correlate with TNF-α expression. Hsa-miR-145-5p can interact to TMEM9B, and then TMEM9B may stimulate IL-6 expression. Thereafter, inflammatory cytokines (TNF-α, IL-1B, IL-6, IL-10 and IL-18) interact each other, leading the upregulation of lesion derived G-CSF level.

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