Table 2 Fifty-two candidate genes and the LOD score of each in the pedigree.

From: Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome

No Gene Associated disease Official name Chromosome Start* End* LOD score**
1 APP Alzheimer’s disease APP 21 27,252,861 27,543,446 Less than 0
2 PSEN1 Alzheimer’s disease PSEN1 14 73,603,143 73,690,399 Less than 0
3 PSEN2 Alzheimer’s disease PSEN2 1 227,057,885 227,083,804 Less than 0
4 MAPT Frontotemporal lobar degeneration MAPT 17 43,971,702 44,105,700 Less than 0
5 C9ORF72 Frontotemporal lobar degeneration C9ORF72 9 27,546,543 27,573,864 Less than 0
6 TARDBP Frontotemporal lobar degeneration TARDBP 1 11,072,462 11,085,549 Less than 0
7 FUS Frontotemporal lobar degeneration FUS 16 31,191,431 31,206,192 Less than 0
8 VCP Frontotemporal lobar degeneration VCP 9 35,056,065 35,072,739 Less than 0
9 GRN Frontotemporal lobar degeneration GRN 17 42,422,491 42,430,474 Less than 0
10 CHMP2B Frontotemporal lobar degeneration CHMP2B 3 87,276,413 87,304,698 Less than 0
11 DNAJB6 Frontotemporal lobar degeneration DNAJB6 7 157,129,692 157,210,133 Less than 0
12 PRNPIP Other dementia ERI3 1 44,686,742 44,821,315 Less than 0
13 CSF1R Other dementia CSF1R 5 149,432,854 149,492,935 Less than 0
14 SNCA Parkinsonism SNCA 4 90,645,250 90,759,447 Less than 0
15 PARK2 Parkinsonism PARK2 6 161,768,590 163,148,834 1.4769
16 UCHL1 Parkinsonism UCHL1 4 41,258,898 41,270,446 1.4769
17 LRRK2 Parkinsonism LRRK2 12 40,618,813 40,763,087 Less than 0
18 PINK1 Parkinsonism PINK1 1 20,959,948 20,978,004 Less than 0
19 DJ1 Parkinsonism PARK7 1 8,021,714 8,045,342 Less than 0
20 ATP13A2 Parkinsonism ATP13A2 1 17,312,453 17,338,467 Less than 0
21 GIGYF2 Parkinsonism GIGYF2 2 233,562,015 233,725,287 Less than 0
22 Omi/HTRA2 Parkinsonism HTRA2 2 74,756,532 74,760,683 Less than 0
23 PLA2G6 Parkinsonism PLA2G6 22 38,507,502 38,577,857 Less than 0
24 FBXO7 Parkinsonism FBXO7 22 32,870,707 32,894,818 Less than 0
25 NUCKS1 Parkinsonism NUCKS1 1 205,681,947 205,719,372 Less than 0
26 VPS35 Parkinsonism VPS35 16 46,693,589 46,723,144 Less than 0
27 EIF4G Parkinsonism EIF4G1 3 184,032,283 184,053,146 Less than 0
28 DCTN1 Parkinsonism DCTN1 2 74,588,281 74,619,214 Less than 0
29 POLG1 Mitochondrial disease POLG 15 89,859,536 89,878,026 Less than 0
30 POLG2 Mitochondrial disease POLG2 17 62,473,902 62,493,184 Less than 0
31 PEO1 Mitochondrial disease C10orf2 10 102,747,293 102,754,159 Less than 0
32 ANT1 Mitochondrial disease SLC25A4 4 186,064,417 186,071,538 Less than 0
33 STX6 Progressive supranuclear palsy STX6 1 180,942,164 180,992,074 Less than 0
34 EIF2AK3 Progressive supranuclear palsy EIF2AK3 2 88,856,259 88,927,094 Less than 0
35 MOBP Progressive supranuclear palsy MOBP 3 39,509,064 39,570,988 Less than 0
36 GBA Others GBA 1 155,204,239 155,214,653 Less than 0
37 NPC1 Others NPC1 18 21,086,148 21,166,581 Less than 0
38 CYP27A1 Others CYP27A1 2 219,646,472 219,680,016 Less than 0
39 TNPO1 Others TNPO1 5 72,112,418 72,210,215 Less than 0
40 UBQLN1 Others UBQLN1 9 86,274,878 86,323,168 Less than 0
41 UBQLN2 Others UBQLN2 X 56,590,025 56,593,443 Not analysed
42 SQSTM1 Others SQSTM1 5 179,233,388 179,265,078 Less than 0
43 ATXN1 Others ATXN1 6 16,299,343 16,761,721 Less than 0
44 ATXN2 Others ATXN2 12 111,890,018 112,037,480 Less than 0
45 ATXN3 Others ATXN3 14 92,524,896 92,572,965 1.4769
46 ATN1 Others ATN1 12 7,033,626 7,051,484 Less than 0
47 TBP Others TBP 6 170,863,384 170,881,958 Less than 0
48 GFAP Others GFAP 17 42,982,994 42,992,920 Less than 0
49 RGPD5 Others RGPD5 2 110,550,335 110,615,268 Less than 0
50 RAN Others RAN 12 131,356,617 131,362,220 Less than 0
51 DNAJC6 Others DNAJC6 1 65,720,133 65,881,552 Less than 0
52 NOP56 Others NOP56 20 2,633,178 2,639,039 Less than 0
  1. *Chromosome numbers and positions are based on GRCh37.p13.
  2. **The maximum LOD in the linkage analysis of this family was 1.4769.