Figure 8 | Scientific Reports

Figure 8

From: Thrombin@Fe3O4 nanoparticles for use as a hemostatic agent in internal bleeding

Figure 8

Scheme of synthesis for the hemostatic THR@ferria colloid. After mixing the Fe2 +/Fe3 + salts, an ammonia solution is added (a) followed by washing the precipitate of the formed magnetite (b) and treating it ultrasonically to yield a stable hydrosol (c). Then, the solution of thrombin (d) is added to the sol and the system is condensed by removal of the solvent and physical gelation. The resulting composite with entrapped thrombin molecules is ground (e) and a hemostatic colloid is prepared by filtering the ground nanoparticles through a filter with a nozzle of 200 nm.

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