Figure 6 | Scientific Reports

Figure 6

From: Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium

Figure 6

Effects of selenium on the apoptosis, cell viability (MTT), mitochondrial membrane depolarization (JC-1), intracellular ROS production and caspase 3 and 9 values through TRPV1 (a,c and e) and TRPM2 (b,d and f) channel activations in the DRGN of FM-induced rats (mean ± SD and n = 3). Values expressed as fold increase (experimental/control). These neurons were dissected from control, FM and treated animals. The TRPV1 and TRPM2 gates in the neurons were opened with capsaicin (10 μM) and cumene hydroperoxide (1 mM) although they were blocked by CPZ (0.1 mM) and ACA (0.025 mM), respectively. (a p ≤ 0.05 and b p ≤ 0.001 versus control and control + CPZ groups. c p ≤ 0.05 versus Se group. d p ≤ 0.001 versus Se and Se + CPZ groups. e p ≤ 0.001 versus FM and FM + CPZ groups. f p ≤ 0.05 versus FM + Se groups).

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