Figure 5 | Scientific Reports

Figure 5

From: Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium

Figure 5

Effects of selenium (Se) on TRPM2 channel activation in dorsal root ganglion neuron (DRGN) of fibromyalgia (FM)-induced rat. The TRPM2 currents in DRGN were stimulated by intracellular ADPR (1 mM in patch pipette) but they were blocked by extracellular TRPM2 antagonist (ACA and 0.025 mM) in the patch-chamber. W.C. is whole cell. Control (without FM induction and stimulation): Original recordings from control neuron. (b) Control + ADPR group (without FM induction). (c) FM group (with FM induction). (d) FM + Se group: The rats received Se after FM induction. (e) Se group: The rats received Se without FM induction. (f) TRPM2 channel current densities in the DRGN. The numbers in parentheses indicated n numbers of groups were indicated by numbers in parentheses. (a p ≤ 0.001 versus control. b p ≤ 0.001 versus control + ADPR group. c p ≤ 0.001 versus control + ADPR + ACA group. d p ≤ 0.001 versus FM + ADPR group. e p ≤ 0.001 versus FM + ADPR + ACA group).

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