Figure 2 | Scientific Reports

Figure 2

From: Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium

Figure 2

Effect of selenium (Se) treatment on [Ca2+]i concentration through block of TRPV1 gate in dorsal root ganglion neuron (DRGN) (a) and sciatic nerve (SciN) (b) of control and FM-induced rats. (n = 8–10 and mean ± SD). The animals received intraperitoneal Se for 2 weeks after FM induction. Then, these dissected neurons of control and FM groups were further in vitro treated with CAPS (10 μM) and CPZ (0.1 mM) before loading Fura-2 for 120 seconds. (a p ≤ 0.05 and b p ≤ 0.001 versus control. c p ≤ 0.001 and d p ≤ 0.05 versus control + CPZ and Se groups. e p ≤ 0.001 versus FM group (2c).

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