Figure 5 | Scientific Reports

Figure 5

From: Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs)

Figure 5

Resveratrol pretreatments blocked the reduction of GABAergic inhibition to dopamine neurons induced by cocaine conditioning. (a) Representative sIPSCs recorded from VTA dopamine neurons in slices prepared from saline- or cocaine-conditioned mice pre-treated with vehicle or resveratrol (Resv). (b,c) The average frequency (b) and amplitude (c) of sIPSCs in VTA dopamine neurons in these four groups of mice. The mean frequency and amplitude of sIPSCs were significantly decreased in cocaine-conditioned, vehicle-treated mice (***p < 0.001, n = 12–13), and this decrease was blocked by resveratrol pretreatments (***p < 0.001, n = 12–13). (d,e) Cumulative probability plots indicate that cocaine exposure led to shifts in the distribution of the inter-event intervals (d) and amplitude (e) in vehicle-treated mice; these shifts were blocked by resveratrol pretreatments (p < 0.001, n = 12–13).

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