Table 4 Dissemination of HIV-1 in humanized mice following intravaginal infection.

From: Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice

Mouse # Uninfected Controls Low Dose (103) 1 Week High Dose (105) 1 Week Low Dose (103) 5 Weeks High Dose (105) 5 Weeks
112-5 110-4 5-1 Total 152-1 129-1 125-5 Total 125-4 120-1 123-2 Total 4-2 4-5 118-2 Total 5-3 2-2 1-3 Total
Plasma 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Vaginal Wash Not collected + + + 3/3 + + 2/3 + + 2/3 + 1/3
Heart 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Vaginal Tract 0/3 + + + 3/3 + + 2/3 + + + 3/3 + + + 3/3
Rectum 0/3 + 1/3 + + 2/3 + + + 3/3 + + + 3/3
Colon 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Small Intestine 0/3 0/3 0/3 + + + 3/3 0/3
Kidney 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Liver 0/3 + 1/3 + + 2/3 + + + 3/3 + + + 3/3
Spleen 0/3 + 1/3 + + 2/3 + + + 3/3 + + + 3/3
Lung 0/3 + + 2/3 + + + 3/3 + + + 3/3 + + + 3/3
Brain 0/3 0/3 0/3 + + + 3/3 + + + 3/3
Skeletal Muscle 0/3 + 1/3 + + 2/3 + + + 3/3 + + + 3/3
Bone Marrow 0/3 + 1/3 + + 2/3 + + + 3/3 + + + 3/3
Uteri 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Bladder 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Thymus 0/3 + 1/3 + 1/3 + + + 3/3 + + + 3/3
Mesenteric LN 0/3 + 1/3 + + 2/3 + + + 3/3 + + 2/3
Infected Tissues 0/17 0/17 0/17 0/51 0% 16/18 2/18 3/18 21/51 0% 5/18 10/18 8/18 26/54 48% 17/18 18/18 18/18 53/54 98% 15/18 16/18 17/18 48/54 89%