Table 3 The association between the plasma HIV-1 titre (copies/mL) in humanized mice and listed covariables was estimated in a multivariate linear mixed effects model with repeated measures. P < 0.05 was considered significant.

From: Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice

Variable Linear Mixed Effects Model gives the probability that the Blood Titre for HIV-1 following Intra-vaginal Challenge depends on the Independent Variables Listed
Adjusted Regression Coefficient β (95%CI)^ P Adjusted Regression Coefficient β (95%CI)$ P Adjusted Regression Coefficient β (905%CI)# P
Plasma Titre (N=161) §
CD45 (>10%) 3.27 (1.62–4.92) <0.001 1.98 (0.83–4.29) 0.004 2.56 (0.83–4.29) 0.004
CD3 (% of CD45) 0.001 (−0.04–0.04) 0.96     
CD45*CD3 (%) 0.21 (0.07–0.40) 0.005 0.144 (−0.005–0.29) 0.062 1.98 (0.19–3.78) 0.032
Viral Dose (High) 2.98 (1.22–4,73) <0.001     
  1. §Total number of plasma titres available from mice at week 1, 3, and/or 5 post-infection.
  2. ^Adjusted by Time.
  3. $Adjusted by Time and Dose.
  4. #Adjusted by Time, Dose, and CD45.