Table 2 Body weight and organ mass in sedentary or exercised or NMN treated offspring of obese mothers that consumed chow or HFD post-weaning.

From: Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

  CCS CHS HCS HCX HCN HHS HHX HHN
Final BW (g) 18.1 ± 0.2 20.9 ± 0.1 19.5 ± 0.3 18.5 ± 0.3X 18.7 ± 0.2^ 28.04 ± 1.2 24.3 ± 0.9XX 24.8 ± 0.7^
Liver (mg) 765 ± 14 693 ± 13 779 ± 43 758 ± 23 811 ± 18 852 ± 27 779 ± 26 763 ± 22
Muscle (mg)
   Quad 236 ± 10 256 ± 11 247 ± 10 254 ± 12 272 ± 6 295 ± 8 303 ± 5 304 ± 7
   AT 82 ± 4 88 ± 3 87 ± 3 86 ± 3.21 87 ± 3 98 ± 5 110 ± 4 100 ± 5
   Soleus 12.4 ± 0.7 15.9 ± 0.7 15.1 ± 0.7 15.0 ± 0.5 16.3 ± 1.1 19.6 ± 0.6 20.2 ± 0.5 19.2 ± 0.7
WAT (mg)
   Gonadal 141 ± 8 601 ± 89 231 ± 22 231 ± 14 202 ± 15 1348 ± 16 946 ± 149X 923 ± 92^
   Inguinal 165 ± 11 463 ± 57 207 ± 13 232 ± 14 196 ± 5 823 ± 108 512 ± 66XXX 532 ± 58^^
   RP 26.1 ± 2.3 143.0 ± 25.2 44.5 ± 4.2 43.1 ± 2.4 40.5 ± 2.2 347.5 ± 33.5 252.0 ± 38.2XX 220.5 ± 22.1^^^
Plasma Insulin (ng/mL) 0.085 ± 0.020 0.154 ± 0.016 0.166 ± 0.020 0.224 ± 0.037 0.317 ± 0.030^ 0.420 ± 0.0.038 0.469 ± 0.033 0.588 ± 0.064^^
Plasma Triglycerides (mg/mL) 2.82 ± 0.24 3.21 ± 0.16 2.94 ± 0.11 3.38 ± 0.23 2.31 ± 0.41 3.62 ± 0.22 3.83 ± 0.24 3.14 ± 0.26
Main effects of the ANOVA analysis of HC, HCX, HCN, HH, HHX, HHN offspring  
  Intervention Post Weaning Diet Interaction
Kill BW (g) F(2,64) = 6.7, P < 0.01 F(1,64) = 135.5, P < 0.001 ns
Liver (mg) ns ns ns
Muscle (mg) Quad ns F(1,63) = 39.4, P < 0.001 ns
AT ns F(1,64) = 26.1, P < 0.001 ns
Soleus ns F(1,62) = 49.5, p < 0.001 ns
WAT (mg) Gonadal F(1,65) = 3.1, P < 0.05 F(1,65) = 110.7, P < 0.001 ns
Inguinal F(1,62) = 3.7, P < 0.05 F(1,62) = 74.9, P < 0.001 F(1,62) = 4.3, P < 0.05
RP F(1,63) = 4.6, P < 0.05 F(1,63) = 157.3, P < 0.001 F(1,63) = 4.1, P < 0.05
Plasma Insulin (ng/mL) F(1,49) = 7.2, P < 0.01 F(1,49) = 54.7, P < 0.001 ns
Plasma Triglycerides (mg/mL) F(1,50) = 5.9, P < 0.01 F(1,50) = 9.6, P < 0.01 ns
  1. Data are shown as mean ± SEM, n = 11–12 per group. The first letter indicates maternal diet, chow (C) or HFD (H); second letter indicates post-weaning diet (C or H); the third letter represents intervention; sedentary (S), exercise (X) or NMN (N). To explore the impact of post-weaning diet and intervention (exercise and NMN) on body weight and tissue phenotypes, the offspring groups HCS, HCX, HCN and HHS, HHX, HHN were analysed by a two-way mixed ANOVA presented upper section of the table. Offspring from lean mothers (CCS & CHS) are shown for comparison. Abbreviations: BW, body weight; WAT, white adipose tissue. Overall effects are presented in the bottom section of the table. The significant effects are:
  2. XP < 0.05, XXP < 0.01, XXXP < 0.001 simple main effect of exercise.
  3. ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 simple main effect of NMN.