Table 1 Body weight and organ mass in offspring of lean and obese mothers that consumed chow or HFD post-weaning

From: Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

   Overall Effects
  CCS CHS HCS HHS Maternal diet Post Weaning Diet Interaction
Final BW (g)   18.1 ± 0.2 20.9 ± 0.1*** 19.5 ± 0.3 28.04 ± 1.2†††/*** F(1,52) = 62.33,P < 0.001 F(1,52) = 110.37, P < 0.001 F(1,52) = 27.24, P < 0.001
Liver (mg)   765 ± 14 693 ± 13* 779 ± 43 852 ± 27††† F(1,48) = 11.9, P < 0.001 ns F(1,48) = 8.4, P < 0.01
Muscle (mg) Quad 236 ± 10 256 ± 11 247 ± 10 295 ± 8 F(1,50) = 5.7, P < 0.05   ns
AT 82 ± 4 88 ± 3 87 ± 3 98 ± 5 F(1,52) = 4.2, P < 0.05 F(1,52) = 4.9, p < 0.05 ns
Soleus 12.4 ± 0.7 15.9 ± 0.7 15.1 ± 0.7 19.6 ± 0.6 F(1,51) = 21.6, P < 0.001 F(1,51) = 34.7, p < 0.001 ns
WAT (mg) Gonadal 141 ± 8 601 ± 89*** 231 ± 22 1348 ± 164†††/*** F(1,51) = 22.3, P < 0.001 F(1,51) = 79.1, P < 0.001 F(1,51) = 13.7, P < 0.001
Inguinal 165 ± 11 463 ± 57*** 207 ± 13 823 ± 108†††/*** F(1,49) = 12.4, P < 0.001 F(1,49) = 63.7, P < 0.001 F(1,49) = 7.7, P < 0.01
RP 26.1 ± 2.3 143.0 ± 25.2*** 44.5 ± 4.2 347.5 ± 33.5†††/*** F(1,52) = 29.9, P < 0.001 F(1,52) = 106.5, P < 0.001 F(1,52) = 20.9, P < 0.001
Plasma Insulin (ng/mL)   0.085 ± 0.020 0.154 ± 0.016*** 0.166 ± 0.020 0.420 ± 0.0.038†††/*** F(1,32) = 38.2, P < 0.001 F(1,32) = 33.2, P < 0.001 F(1,32) = 10.9, P < 0.01
Plasma Triglycerides (mg/mL) 2.82 ± 0.24 3.21 ± 0.16** 2.94 ± 0.11 3.62 ± 0.22** ns F(1,36) = 7.8, P < 0.01 ns
  1. Data are shown as mean ± SEM, n = 11–16 per group. The first letter indicates maternal HFD, chow (C) or HFD (H); second letter indicates post-weaning diet (C or H); the third letter represents intervention; sedentary (S). To explore the impact of maternal and post-weaning diet on body weight and tissue phenotypes in the sedentary offspring groups CCS, CHS, HCS and HHS were analysed by two-way mixed ANOVA. Abbreviations: BW, body weight; WAT, white adipose tissue. Main effects are presented in the right hand panel. The significant effects are:
  2. ††† P < 0.001 overall maternal HFD effect.
  3. * P < 0.05, *** P < 0.001 overall post-weaning diet effect.
  4. ns, no significant difference.