Figure 2 | Scientific Reports

Figure 2

From: Imaging Monitoring of Kupffer Cell Function and Hepatic Oxygen Saturation in Preneoplastic Changes During Cholangiocarcinogenesis

Figure 2

Preneoplastic Changes during Cholangiocarcinogenesis. (A) The livers of the control group showed a normal appearance of hepatocytes, cholangiocytes, and portal triad without evidence of inflammation (original magnification; left: ×40 and right: ×200, scale bars = 50 µm). (B) The experimental group showed that there was bile ductular reaction with a periductular inflammatory infiltrate (arrows), zonal necrosis (star), and epithelial hyperplasia (arrowheads) at six weeks (original magnification; ×40, scale bars = 50 µm). (C) At eight weeks, there was granulation tissue and bile ductular reaction (white stars) adjacent to necrotic area. An extensive bile ductular reaction with a periductular inflammatory infiltrate (arrows), and the cystic dilatation with epithelial hyperplasia (black star) were noted around the small portal tract (original magnification; ×40, scale bars = 50 µm). (D) The large bile duct showed that there was biliary epithelial hyperplasia with irregularly shaped ductal architecture (arrow), and the lining epithelium had enlarged nuclei and slightly distorted polarity (white stars) (original magnification; left ×40 and right: ×200, scale bars = 50 µm). These findings was consistent with preneoplastic changes during cholangiocarcinogenesis.

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