Figure 8: | Scientific Reports

Figure 8

From: miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome

Figure 8

5-HT4 receptor mediated function in the intestine. 5-HT4 receptor activation promotes GI motility at different levels. Decreased miR-16 and miR-103 levels as well as hypermorphic allele variants (c.*61 T > C) may lead to elevated 5-HT4 receptor activity resulting in increased secretion and peristalsis in all or particular subregions and make individuals more susceptible to develop diarrhoea. Figure components were kindly provided from Servier Medical Art (http://www.servier.com). This work is licensed under the Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. The authors acknowledge the free figure access.