Table 1 Medical conditions associated with differentially abundant proteins identified in this study.

From: Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

Protein Condition Reference
FCRL3 autoimmune thyroid disease 30
FCRL3 rheumatoid arthritis 30
FCRL3 systematic lupus erythematosus 30
FCRL3 neuromyelitis optica 32
Complement (C1QA, C1S, C1R, C3, C6) Alzheimer’s disease 73,74,75
Complement (C1QA, C1S, C1R, C3, C6) systematic lupus erythematosus 63,65
Complement (C1QA, C1S, C1R, C3, C6) type I interferonopathies 64
IL-10 systematic lupus erythematosus 50
IL-17 systematic lupus erythematosus 52
IL-6 Sjogren’s syndrome 56
IL-6 rheumatoid arthritis 57
IP-10 Aicardi-Goutieres Syndrome 59
M1 Amiopeptidases (ERAP2) ankylosing spondylitis 44
M1 Amiopeptidases (ERAP2) inflammatory bowel disease 44
M1 Amiopeptidases (ERAP2) Behçet’s disease 44
M1 Amiopeptidases (ERAP2) autoimmune type 1 diabetes 48
M1 Amiopeptidases (ERAP2) psoriasis 44,45
TNF-α systematic lupus erythematosus 50
TNF-α Down syndrome 53
TNF-α Sjogren’s syndrome 56
TNF-α rheumatoid arthritis 57
TNF-α Aicardi-Goutieres Syndrome 58
TNFRSF1A systematic lupus erythematosus 51
TNFRSF1B systematic lupus erythematosus 51
VEGF Aicardi-Goutieres Syndrome 60
ZAP70 severe combined immunodeficiency 38
ZAP70 immunodeficiency 48 39
ZAP70 Infantile-Onset Multisystem Autoimmune Disease 2 40
ZAP70 autoimmune arthritis (mice) 41
FGFR1 myeloproliferative disorders 78
FGFR1 craniofacial abnormalities 76,77
RET Hirschsprung’s disease 84