Figure 2 | Scientific Reports

Figure 2

From: Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

Figure 2

People with Down syndrome show a proteomic signature indicative of profound immune dysregulation. (a) Metascape analysis highlighting interconnected protein networks involved in Immune Control among the differential proteins in the Discovery Study. (b) STRING analysis identifies interacting groups of deregulated proteins within the Immune Control functional category. (c–j) Box and whisker plots of SOMAscan® data for individual proteins deregulated in individuals with T21. p(a) values from KS test with Bonferroni correction. (k) Heatmap displaying the results of a Mesoscale Discovery Assay (MSD) measuring the levels of 38 inflammatory markers in a cohort of 40 adult individuals, 20 of them with T21. Proteins are ranked from the most significantly different (top, IL-6) to not significantly different (bottom, IL-1α). The horizontal dashed line marks the p(a) <0.1 cut-off. (lp) Box and whisker plots for the top five most different inflammatory markers detected in the MSD assay, all of which are elevated in people with DS. p(a) values from KS test with Benjamini-Hochberg correction.