Figure 2 | Scientific Reports

Figure 2

From: HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD

Figure 2

Increased de novo lipogenesis and mRNA levels of LXR-regulated lipogenic genes in liver of Vpr-Tg and sVpr-treated mice. (A) Faster conversion of [14C]acetate into [14C]-labeled fatty acids in primary hepatocytes was noted in Vpr-Tg compared to WT mice (N = 3 per group). (B) Increased mRNA levels of Chrebp and its target Lpk were present in Vpr-Tg compared to WT mice (N = 8 per group). (C) mRNA levels of Dgat, Fasn and Scd1 were present in Vpr-Tg compared to WT mice (N = 8 per group). (D) mRNA levels of Chrebp and Lpk were increased, and there was a trend towards increased mRNA level of Srebp1c (P = 0.077), in sVpr-treated compared to vehicle-treated mice (N = 8 per group). (E) Increased mRNA levels of Dgat, Fasn, Scd1 and Acc were noted in sVpr-treated compared to vehicle-treated mice (N = 8 per group). Values are mean ± SE. *P < 0.05, **P < 0.01, ***P < 0.001.

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