Figure 6 | Scientific Reports

Figure 6

From: An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy

Figure 6

PEGylation dramatically improves the penetration of the construct into 3D tumor spheroids. The construct lacking the PEG chain only reaches cells at the nodule periphery and is mostly bound to the layer of extracellular matrix that surrounds the spheroid (A). The PEGylated construct, on the other hand, has minimal extracellular matrix binding and is taken up within cells throughout the spheroid (B).

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