Figure 4 | Scientific Reports

Figure 4

From: An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy

Figure 4

The EtNBS construct experiences greater uptake in cells that overexpress the α5 integrin. To better show the range of construct uptake, the images are false colored in a blue-green-white color scale. The contrast in both images arises from the native near-infrared fluorescence of the EtNBS molecule when excited at 635 nm. Both the normal OVCAR5 (A) and an OVCAR5 cell line engineered to ectopically overexpress the α5 integrin (B) were incubated with the EtNBS construct. The cell line with greater integrin expression demonstrated greater uptake of the construct via confocal fluorescence microscopy (B).

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